Neurovascular sequestration in paediatric P. falciparum malaria is visible clinically in the retina
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چکیده
منابع مشابه
The Use of Crude Plasmodium falciparum Antigens for Comparison of Antibody Responses in Patients with Mild Malaria vs. Cerebral Malaria
Background: Cerebral malaria (CM) is one of the major causes of death in African populations infected with Plasmodium falciparum. Only 1% of infected subjects develop CM. The reasons for these differences are not fully understood, but it is likely that the host humoral response against blood-stage antigens plays a role in protection from malaria, although the precise targets and mechanisms medi...
متن کاملCerebral malaria in children: using the retina to study the brain
Cerebral malaria is a dangerous complication of Plasmodium falciparum infection, which takes a devastating toll on children in sub-Saharan Africa. Although autopsy studies have improved understanding of cerebral malaria pathology in fatal cases, information about in vivo neurovascular pathogenesis is scarce because brain tissue is inaccessible in life. Surrogate markers may provide insight into...
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UNLABELLED To evaluate the frequency and severity of jaundice with hepatic dysfunction in Plasmodium (P.) falciparum malaria in adult patients admitted in the hospital. STUDY DESIGN Descriptive study. PLACE AND DURATION OF STUDY The Infectious Diseases Unit and Medical Wards at Rashid Hospital, Dubai, United Arab Emirates, from January 2005 to December 2007. METHODOLOGY This study include...
متن کاملKnobless Parasitized Rbc in Fatal P. Falciparum Malaria
We present a case report of fatal falciparum malaria of a splenectomized adult Thai patient. The patient developed high peripheral parasitemia and showed signs of severe malaria with multiorgans involvement. Ultrastructure of Plasmodium falciparum -infected red blood cells in a fatal splenectomized patient and pathological features are reported for the first time with special emphasis on the ro...
متن کاملSevere P. falciparum malaria in Kenyan children: evidence for hypovolaemia.
BACKGROUND The role of volume resuscitation in severe Plasmodium falciparum malaria is controversial. AIM To examine the role of hypovolaemia in severe childhood malaria. STUDY DESIGN Retrospective review. METHODS We studied 515 children admitted with severe malaria to a high-dependency unit (HDU) in Kilifi, Kenya. On admission to the HDU, children underwent a further assessment of vital ...
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ژورنال
عنوان ژورنال: eLife
سال: 2018
ISSN: 2050-084X
DOI: 10.7554/elife.32208